USC vs Notre Dame Prediction, Odds, Line : 2022 Week 13 College Football Picks, Best Bets Based on Proven Model

The rivals go head-to-head Saturday night at the Los Angeles Memorial Coliseum. The No. 6 USC Trojans hosts No. 15 Notre Dame Fighting Irish in the regular season finals for both programs. Notre Dame is 8-3 and on a four-game winning streak. USC is 10-1 overall and 6-0 at home, and has an appearance in the Pac-12 championship game next week.

Kickoff is at 7:30 p.m. ET in Los Angeles. Caesars Sportsbook lists the Trojans as 5-point home favorites while the over/under, or total number of points Vegas believes will be scored, is 64.5 in the latest Notre Dame vs. USC odds. Before you decide on USC vs. Notre Dame, be sure to check out the college football predictions and betting advice from SportsLine’s trusted computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. For the last 6+ years, the proprietary computer model has generated a staggering nearly $3,000 in profits for $100 players using its top-flight college football picks against the spread. Everyone who has followed it has seen huge returns.

Now the model has his sights set on USC vs. Notre Dame and has just revealed his picks and CFB predictions. You can now visit SportsLine to see the model selection. Now here are some college football odds and trends for Notre Dame vs. USC:

  • Spread between Notre Dame and USC: USC -5
  • Notre Dame vs. USC Over/Under: 64.5 points
  • Notre Dame vs. USC money line: USC -210, ND +175
  • ND: The Irish are 6-5 against the spread this season
  • USC: The Trojans are 7-4 against the spread this season
  • Notre Dame vs. USC picks: See picks at SportsLine

Featured Game | USC Trojans vs Notre Dame Fighting Irish

Why Notre Dame can cover

Notre Dame has the superior defense in this matchup. The Fighting Irish, led by Marcus Freeman, are allowing just 20.3 points per game, and Notre Dame is in the FBS’s top 20 in total yards allowed (317.2 per game). Notre Dame excels on the pass and run, with the Irish giving up less than 190 passing yards per game. Opponents complete just 56.5% of pass attempts against Notre Dame, with the Fighting Irish producing 33 sacks, a top 15 mark in the nation.

Junior defenseman Isaiah Foskey is in the FBS top 10 with 9.5 sacks, and Notre Dame holds opponents to a third with a 34% efficiency rate. On the other hand, USC allows 405 total yards per game, including 257.8 passing yards per contest, and the Trojans give up 4.6 yards per carry.

Why USC can cover

USC is absolutely on offense this season, leading to a potential path toward the college football playoffs. The Trojans are averaging 42.9 points per game, #3 among FBS teams this season. USC has scored 40 points or more in five straight games, and the Trojans have a school record with nine games with at least 40 points. The Trojans are No. 2 in the country in total yards per game at 513.0, and USC is No. 4 in the country in passing offense, producing 330.8 yards per game through the air.

USC is in the top ten in the country at 9.1 yards per attempted pass, and the team has 34 passing touchdowns and just three interceptions this season. Caleb Williams is a Heisman Trophy contender at quarterback, and USC also has strong running game. The Trojans average 182.2 rushing yards per game, a top-five mark in the Pac-12, and USC average 5.3 yards per carry. In addition to explosiveness, USC ranks #2 in the nation in third-down efficiency at 54.3%.

How to make USC vs. Notre Dame picks

SportsLine’s model takes the grand total and projects the teams to 61 points. The model also says that one side of the spread hits well over 50% of the time. The model selection is only available from SportsLine.

So, who will win Notre Dame vs. USC? And which side of the spread applies well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump to, all from the model who crushed his college football picks, and find out.

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