Louisville vs. South Florida odds, line: 2022 college football picks, week 4 predictions from proven model

The Louisville Cardinals and South Florida Bulls will both be looking to get back to the 500 mark in the season when they play each other Saturday. Louisville had a chance to win its Final Drive game against Florida State last week, but an interception ended the Cardinals in a 35-31 final. South Florida nearly threw up a major Florida upset before botching a late field goal attempt.

Kick-off is set for noon ET. The Cardinals are favored at 14.5 points in the latest Louisville vs. South Florida odds from Caesars Sportsbook, while the over/under is set at 64.5. Before entering any South Florida vs. Louisville predictions, check out SportsLine’s advanced computer model college football predictions.

The SportsLine projection model simulates every FBS college football game 10,000 times. For the last 6+ years, the proprietary computer model has racked up a staggering $3,300+ win for $100 players using its top-flight college football picks against the spread. It goes into Week 4 of the 2022 college football season with a 51-43 run on all the top-flight college football spreads and money line picks going back to 2021. Anyone who has followed it has seen tremendous returns.

Now the model has Louisville vs. South Florida in her sights. You can go to SportsLine to see the selection. Here are some college football odds for Louisville vs. South Florida:

  • Spread between Louisville and USF: Louisville -14.5
  • Louisville vs. USF over/under: 64.5 points
  • Louisville vs. USF Picks: See picks here

Featured Game | Louisville Cardinals vs. South Florida Bulls

Why Louisville can cover

Louisville will be at home for the second straight week after playing two away games to open the season. The Cardinals are also playing an extra day off after their loss to Florida State last week, making this a strong planning point. They led 31-28 in the fourth quarter before allowing the Seminoles to score the final touchdown of the game. Louisville quarterback Malik Cunningham hasn’t lived up to expectations so far this season, but the senior should start turning things around.

He threw for nearly 3,000 yards and 19 touchdowns last year while rushing for more than 1,000 yards. Cunningham threw for 243 yards and rushed for 127 against Florida State last week and he will face a less talented defense this week. USF is on a 10-game losing streak, having won just once in their last eight games overall.

Why South Florida can cover

South Florida has shown tremendous signs of improvement this season, especially with its performance last week. The Bulls delivered a 42-20 win over Howard in Week 2 before nearly beating a top-ranked Florida team on the road. They had a chance to level the game in the final moments, but a botched field goal attempt was the final blow.

Regardless, South Florida will bring a new level of confidence to this street game. The Bulls also have 20+ points in all three games, something Louisville can’t claim. In addition, Louisville has only won and covered once in their last five games.

How to make Louisville vs. South Florida picks

The model ran South Florida vs. Louisville 10,000 times and the results are in. We can tell you that the model is leaning forward and it also generated a point spread pick that hits in almost 60% of the simulations. You can only see the selection at SportsLine.

So who will win Louisville vs. South Florida? And which side of the spread is correct in almost 60% of the simulations? Visit SportsLine now to find out which side of the South Florida vs. Louisville span to jump on Saturday, all from the model who crushed his college football picks and find out.

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