Clemson vs. Wake Forest odds, prediction, line: 2022 week 4 college football picks by model on 51-43 run

The No. 5 Clemson Tigers are looking to continue their winning streak when they take on the No. 21 Wake Forest Demon Deacons in an ACC Atlantic Division matchup on Saturday. The Tigers (3-0) come into the game after winning nine straight wins, which is the nation’s longest active winning streak. The Demon Deacons (3-0) want to build on the success of last year, in which they won the division 7-1 and ended 11-3 overall. Clemson was second in the division, 6-2 and 10-3 overall.

Truist Field’s kickoff in Winston-Salem, NC is scheduled for 12:00 p.m. ET. Clemson leads the all-time streak 69-17-1, including a 26-10-1 record at Wake Forest. The Tigers are 7-point favorites in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over/under for total points scored is set at 55.5. Before making a choice between Wake Forest and Clemson, you need to look at SportsLine’s advanced computer simulation model for college football predictions and betting recommendations.

The SportsLine projection model simulates every FBS college football game 10,000 times. For the last 6+ years, the proprietary computer model has racked up a staggering $3,300+ win for $100 players using its top-flight college football picks against the spread. It goes into Week 4 of the 2022 college football season with a 51-43 run on all the top-flight college football spreads and money line picks going back to 2021. Anyone who has followed it has seen tremendous returns.

Now the model has set its sights on Clemson vs. Wake Forest and has just laid down its picks and CFB predictions. You can now go to SportsLine to see the model selection. Well, here are some college football odds and betting lines for Wake Forest vs. Clemson:

  • Spread between Clemson and Wake Forest: Clemson -7
  • Clemson vs. Wake Forest Over/Under: 55.5 points
  • Clemson vs. Wake Forest money line: Clemson -285, Wake Forest +228
  • CLEM: The Tigers have played 4-0 against the spread in their last four conference games
  • WF: The Demon Deacons are 4-1 ATS in their last five games in September
  • Clemson vs. Wake Forest tips: See tips at SportsLine

Featured Game | Wake Forest Demon Deacons vs. Clemson Tigers

Why Clemson can cover

The Tigers are averaging more than 41 points per game and are led by junior quarterback DJ Uiagalelei, who has completed 57 of 88 passes (64.8%) for 662 yards and five touchdowns. He has been picked up once but has a rating of 144.4. Uiagalelei can also be a dangerous runner. He is second on the team in rushing for 117 yards on 27 carries (4.3 average) and one touchdown.

Sophomore running back Will Shipley is also a threat. He leads the Tigers in rushing and carries 32 times for 249 yards (7.8 average) and six touchdowns. He also has three receptions for 28 yards (9.3 average), including a 14-yard long. Shipley recorded multiple touchdowns on the floor in each of Clemson’s first three games, giving him multiple rushing touchdowns in seven of his 13 career games played. He’s one of six Clemson players since 2000 to record at least seven career games with multiple rushing touchdowns.

Why Wake Forest can cover

Still, the Tigers aren’t a lock to cover the Clemson vs. Wake Forest spread. That’s because the Demon Deacons also have a strong offense, led by junior quarterback Sam Hartman. Hartman has completed 44 of 71 passes (62%) for 625 yards and seven touchdowns with two interceptions. Last season he was a finalist for the Manning Award and the Johnny Unitas Golden Arm Award. Hartman threw for 4,228 yards in 2021, ranking sixth in ACC history and first in Wake Forest history. He also rushed for 11 touchdowns, the second-highest in program history by a Wake Forest quarterback.

His favorite target was second wide receiver Taylor Morin, who has 13 receptions for 139 yards (10.7 average) and two TDs. In the season opener against VMI on September 1, he led the team with five catches for 74 yards and a touchdown in category. He had at least one reception in every game and multiple receptions in 12 of the 14 games he played.

How to do Wake Forest vs Clemson picks

SportsLine’s model takes total points and projects teams to score a combined 68 points. The model also says that one side of the variance is true in well over 50% of the simulations. You can only see the model’s CFB picks at SportsLine.

So who wins Clemson vs. Wake Forest? And which side of the spread applies in well over 50% of the simulations? Visit SportsLine now to see which side of the spread you need to jump to, all from the model who crushed his college football picks, and find out.

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